• Journal of anesthesia · Mar 1994

    Intravenous magnesium sulfate as a preanesthetic medication: A double-blind study on its effects on hemodynamic stabilization at the time of tracheal intubation.

    • Tetsuro Kagawa, Ryokichi Goto, Katsuhiro Iijima, Yuji Kamikawa, Keiichi Sakai, and Hidefumi Obara.
    • Department of Anesthesia, Hyogo Prefectural Awaji Hospital, Shimogamo 1-6-6, 656, Sumoto, Japan.
    • J Anesth. 1994 Mar 1; 8 (1): 17-20.

    AbstractThe effects of magnesium sulfate (MgSO4) as a preanesthetic medication were studied with regard to whether it can sedate or relieve a patient who is scheduled to undergo surgery, and whether it can control the hemodynamic response to tracheal intubation. Twenty adult patients in ASA status 1-2 undergoing elective surgery were studied. Ten patients received 50 mg·g-1 MgSO4 intravenously by drip infusion from 30 min before the induction of anesthesia, and another ten patients received saline as a control. The changes in mean arterial pressure (MAP) and rate pressure product (RPP) after the intubation were significantly suppressed in magnesium-treated patients, but a sedative effect was not observed. Therefore, MgSO4 was useful as a preanesthetic medication in suppressing the hemodynamic response associated with tracheal intubation.

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