• Diabetes Metab. Res. Rev. · Oct 2015

    Trends in the incidence of diabetes, its clinical sequelae, and associated costs in pregnancy.

    • Lois Jovanovič, Yuanjie Liang, Wayne Weng, Marianthe Hamilton, Lisa Chen, and Neil Wintfeld.
    • Sansum Diabetes Research Institute, Santa Barbara, CA, USA.
    • Diabetes Metab. Res. Rev. 2015 Oct 1; 31 (7): 707-16.

    BackgroundIncreasing diabetes prevalence affects a substantial number of pregnant women in the United States. Our aims were to evaluate health outcomes, medical costs, risks and types of complications associated with diabetes in pregnancy for mothers and newborns.MethodsIn this retrospective claims analysis, patients were identified from the Truven Health MarketScan(®) database (2004-2011 inclusive). Participants were aged 18-45 years, with ascertainable diabetes status [Yes/No], date of birth event >2005 and continuous health plan enrolment ≥21 months before and 3 months after the birth.ResultsIn total, 839 792 pregnancies were identified, and 66 041 (7.86%) were associated with diabetes mellitus [type 1 (T1DM), 0.13%; type 2 (T2DM), 1.21%; gestational (GDM), 6.29%; and GDM progressing to T2DM (patients without prior diabetes who had a T2DM diagnosis after the birth event), 0.23%]. Relative risk (RR) of stillbirth (2.51), miscarriage (1.28) and Caesarean section (C-section) (1.77) was significantly greater with T2DM versus non-diabetes. Risk of C-section was also significantly greater for other diabetes types [RR 1.92 (T1DM); 1.37 (GDM); 1.63 (GDM progressing to T2DM)]. Risk of overall major congenital (RR ≥ 1.17), major congenital circulatory (RR ≥ 1.19) or major congenital heart (RR ≥ 1.18) complications was greater in newborns of mothers with diabetes versus without. Mothers with T2DM had significantly higher risk (RR ≥ 1.36) of anaemia, depression, hypertension, infection, migraine, or cardiac, obstetrical or respiratory complications than non-diabetes patients. Mean medical costs were higher with all diabetes types, particularly T1DM ($27 531), than non-diabetes ($14 355).ConclusionsComplications and costs of healthcare were greater with diabetes, highlighting the need to optimize diabetes management in pregnancy.© 2015 The Authors. Diabetes/Metabolism Research and Reviews published by John Wiley & Sons, Ltd.

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