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- Tie Gang Li, Yong Yan, Na Na Wang, and Min Zhao.
- Emergency Department, Shengjing Hospital of China Medical University, Shenyang 110004, China. litg@sj-hospital.org
- Am J Emerg Med. 2011 Jun 1; 29 (5): 518-22.
AbstractCarbamazepine (CBZ) poisoning has been occurring more frequently. We describe the use of synthesized resin-absorbed hemoperfusion in the therapy of a 48-year-old man who developed carotic, cardiovascular shock and multiorgan dysfunction due to a CBZ overdose (the highest concentration of drug >20 mg/L; therapeutic range, 8-12 mg/L). The treatment was very successful; and the patient eventually was discharged with a full recovery and no complications, although his diagnosis and treatment had been delayed for 56 hours. Hemoperfusion has a steady clearance of this drug without subsequent rebound or potential hazards. Resin hemoperfusion should be first considered for acute CBZ intoxication, especially when drug-induced gastrointestinal hypomotility prevents elimination via the gut and patient is under life-threatening condition.Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.
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