• Naoki Shiraishi, Mayu Aono, Yasuhito Kameyama, Mai Yamamoto, Osamu Kitajima, and Takahiro Suzuki.
• Department of Anesthesiology, School of Medicine, International University of Medical and Welfare, Tokyo, Japan.
• J Anesth. 2018 Aug 1; 32 (4): 547-550.

PurposeThe aim of this study was to elucidate the relationship between the onset of rocuronium-induced neuromuscular block and arterial pressure-based cardiac output (CO) in elderly patients.MethodsForty elderly patients aged 65-83 years were enrolled in this study. After induction of anesthesia, contractions of the adductor pollicis muscle to ulnar nerve train-of-four stimulation were acceleromyographically evaluated and 1 mg/kg rocuronium was administered following CO measurement. The correlation between onset of rocuronium action and CO was analyzed.ResultsThe mean [SD] CO reduced after induction of anesthesia from 5.1 [1.8] L/min to 3.8 [1.1] L/min. The onset time of rocuronium-induced neuromuscular block was 110.3 [23.9] s (range 60-165). There was a statistically significant inverse correlation between the onset time of rocuronium and CO [onset time (s) = - 13.2·CO + 159.7, R2 = 0.376].ConclusionsIn the elderly, CO influences the onset of action of rocuronium.

21 keywords...

hide…