• En-Ling Yeh, Yi-Chia Huang, Shang-Feng Tsai, Tong-Min Yu, Ming-Ju Wu, and Cheng-Hsu Chen.
• Graduate Program in Nutrition, Chung Shan Medical University, Taichung, Taiwan.
• Nutrition. 2018 Sep 1; 53: 103-108.

ObjectivesHemodialysis (HD) with dialysis adequacy could increase the excretion of B vitamins (folate, vitamin B6, and B12) and raise the plasma level of homocysteine. Here we determined the associations of plasma homocysteine with B vitamins in patients with HD adequacy or inadequacy.MethodsWe recruited 68 patients who had received HD treatments (three times a week, 4 h each). Based on the individual's hemogram and quarterly urea reduction rate (Kt/V), patients were pooled into one of the following two groups: the first group with dialysis adequacy (Kt/V > 1.2, n = 48) and the second with dialysis inadequacy (Kt/V ≤ 1.2, n = 20). We also recorded the anthropometric date of each patient and their biochemical data and dietary intakes. Plasma levels of homocysteine, cysteine, folate, pyridoxal 5'-phosphate (PLP), and vitamin B12 were measured twice, once before and once after HD.ResultsThe plasma levels of homocysteine, cysteine, folate, PLP, and vitamin B12 dropped significantly at the end of HD. The plasma levels of vitamin B12 were negatively correlated with the plasma levels of homocysteine, both pre- and post-HD, and in both groups regardless of dialysis adequacy or inadequacy. In contrast, plasma levels of folate and PLP were not correlated with homocysteine at both pre- or post-HD in both groups.ConclusionsThe plasma level of vitamin B12, but not folate or vitamin B6, was negatively correlated with that of homocysteine both before and after HD treatment, and regardless of dialysis adequacy or inadequacy.Copyright © 2018 Elsevier Inc. All rights reserved.

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