• Pavlos Texakalidis, Stefanos Giannopoulos, Damianos G Kokkinidis, Theofilos Karasavvidis, Leonardo Rangel-Castilla, and John Reavey-Cantwell.
• Department of Neurologic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: pavlostex.med@gmail.com.
• World Neurosurg. 2018 Dec 1; 120: 563-571.e3.

BackgroundResults from studies investigating the effect of contralateral carotid occlusion (CCO) in patients with carotid artery stenosis undergoing carotid artery endarterectomy (CEA) or carotid artery stenting (CAS) are variable in the literature. We sought to determine whether CEA or CAS is the optimal revascularization approach for patients with CCO.MethodsThis meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A random effects model meta-analysis was conducted, and the I2 statistic was used to assess for heterogeneity. Subgroup and sensitivity analyses were performed as needed.ResultsFive retrospective observational cohort studies comprising 6346 patients were included. Patients in the CEA group had a significantly lower risk of 30-day periprocedural mortality (odds ratio, 0.46; 95% confidence interval, 0.30-0.71; I2 = 0%). However, no significant differences were identified in terms of stroke, myocardial infarction (MI), and major adverse cardiovascular events (MACEs) between the 2 groups. Subgroup analyses of symptomatic and asymptomatic patients did not yield significant differences for stroke, MI, and death.ConclusionsPatients with CCO can safely undergo both CAS and CEA with similar risks of stroke, MI, and MACE. However, patients treated with CEA have a lower risk of 30-day periprocedural mortality. Future studies can help further clarify the ideal approach for these patients.Copyright © 2018 Elsevier Inc. All rights reserved.

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