• Jason D Doles, Kelly A Hogan, Jennifer O'Connor, Andrea E Wahner Hendrickson, Olivia Huston, and Aminah Jatoi.
• 1 Department of Biochemistry and Molecular Biology, Mayo Clinic , Rochester, Minnesota.
• J Palliat Med. 2018 Sep 1; 21 (9): 1334-1338.

BackgroundMore than 80% of patients with advanced cancer develop weight loss. Because preclinical data suggest poly (ADP-ribose) polymerase (PARP) inhibitors can treat this weight loss, this study was undertaken to explore the PARP inhibitor veliparib for this indication.ObjectiveThe current study was undertaken to analyze prospectively gathered data on weight in cancer patients on PARP inhibitors.Design/SettingThe current study relied on a previously published, prospectively conducted phase 1 single institution trial that combined veliparib and topotecan (NCT01012817) as antineoplastic therapy for advanced cancer patients. Serial weight data and, when available and clinically relevant, computerized tomography scans were also examined.MeasurementsThe primary endpoint was 10% or greater weight gain from trial enrollment.ResultsNearly all 60 patients lost weight over time. Only one patient manifested a 10% or greater gain in weight. However, review of computerized tomography L3 images showed this weight gain was a manifestation of ascites. Four other patients gained 5% of their baseline weight. However, findings in two patients with available radiographs showed no evidence of muscle augmentation.ConclusionsThe addition of the PARP inhibitor veliparib to chemotherapy does not appear to result in notable weight gain or in weight maintenance in patients with advanced cancer. Interventions other than PARP inhibitors should be considered for the palliation/treatment of cancer-associated weight loss.

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