• Neuroscience · May 2016

    Review

    Mouse models of fear-related disorders: Cell-type-specific manipulations in amygdala.

    • G M Gafford and K J Ressler.
    • Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA; Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Atlanta, GA, USA.
    • Neuroscience. 2016 May 3; 321: 108-120.

    AbstractFear conditioning is a model system used to study threat responses, fear memory and their dysregulation in a variety of organisms. Newly developed tools such as optogenetics, Cre recombinase and DREADD technologies have allowed researchers to manipulate anatomically or molecularly defined cell subtypes with a high degree of temporal control and determine the effect of this manipulation on behavior. These targeted molecular techniques have opened up a new appreciation for the critical contributions different subpopulations of cells make to fear behavior and potentially to treatment of fear and anxiety disorders. Here we review progress to date across a variety of techniques to understand fear-related behavior through the manipulation of different cell subtypes within the amygdala. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

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