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- H Hirase and Y Shinohara.
- RIKEN Brain Science Institute, Saitama 351-0198, Japan; Saitama University Brain Science Institute, Saitama 338-8570, Japan. Electronic address: hirase@brain.riken.jp.
- Neuroscience. 2014 Nov 7; 280: 282-98.
AbstractIt has been half a century since brain volume enlargement was first reported in animals reared in an enriched environment (EE). As EE animals show improved memory task performance, exposure to EE has been a useful model system for studying the effects of experience on brain plasticity. We review EE-induced neural changes in the cerebral cortex and hippocampus focusing mainly on works published in the recent decade. The review is organized in three large domains of changes: anatomical, electrophysiological, and molecular changes. Finally, we discuss open issues and future outlook toward better understanding of EE-induced neural changes. Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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