• Neuroscience · May 2019

    Review

    Microglial Priming as Trained Immunity in the Brain.

    • Michael J Haley, David Brough, Jessica Quintin, and Stuart M Allan.
    • Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester M13 9PT, UK.
    • Neuroscience. 2019 May 1; 405: 47-54.

    AbstractIn this review we discuss the possibility that the phenomenon of microglial priming can be explained by the mechanisms that underlie trained immunity. The latter involves the enhancement of inflammatory responses by epigenetic mechanisms that are mobilized after first exposure to an inflammatory stimulus. These mechanisms include long-lasting histone modifications, including H3K4me1 deposition at latent enhancer regions. Although such changes may be beneficial in peripheral infectious disease, in the context of microglial priming they may drive increased microglia reactivity that is damaging in diseases of brain aging.Copyright © 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

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