• Neuroscience · Jul 2020

    Modulation of acid sensing ion channel dependent protonergic neurotransmission at the mouse calyx of Held.

    • Carlota González-Inchauspe, María Natalia Gobetto, and Osvaldo D Uchitel.
    • Instituto de Fisiología, Biología molecular y Neurociencias (IFIBYNE) CONICET. Departamento de Fisiología, Biología Molecular y Celular "Dr. Héctor Maldonado", Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires. Ciudad Universitaria. (C1428EGA) Ciudad Autónoma de Buenos Aires, Argentina. Electronic address: carlota@fbmc.fcen.uba.ar.
    • Neuroscience. 2020 Jul 15; 439: 195-210.

    AbstractAcid-sensing ion channels (ASICs) regulate synaptic activities and play important roles in neurodegenerative diseases. It has been reported that homomeric ASIC-1a channels are expressed in neurons of the medial nucleus of the trapezoid body (MNTB) of the auditory system in the CNS. During synaptic transmission, acidification of the synaptic cleft presumably due to the co-release of neurotransmitter and H+ from synaptic vesicles activates postsynaptic ASIC-1a channels in mice up to 3 weeks old. This generates synaptic currents (ASIC1a-SCs) that add to the glutamatergic excitatory postsynaptic currents (EPSCs). Here we report that neuromodulators like histamine and natural products like lactate and spermine potentiate ASIC1a-SCs in an additive form such that excitatory ASIC synaptic currents as well as the associated calcium influx become significantly large and physiologically relevant. We show that ASIC1a-SCs enhanced by endogenous neuromodulators are capable of supporting synaptic transmission in the absence of glutamatergic EPSCs. Furthermore, at high frequency stimulation (HFS), ASIC1a-SCs contribute to diminish short term depression (STD) and their contribution is even more relevant at early stages of development. Since ASIC channels are present in almost all types of neurons and synaptic vesicles content is acid, the participation of protons in synaptic transmission and its potentiation by endogenous substances could be a general phenomenon across the central nervous system. This article is part of a Special Issue entitled: Honoring Ricardo Miledi - outstanding neuroscientist of XX-XXI centuries.Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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