• A L Manuel, A W David, M Bikson, and A Schnider.
• Laboratory of Cognitive Neurorehabilitation, Department of Clinical Neurosciences, University of Geneva, Switzerland. Electronic address: aurelie.manuelstocker@hcuge.ch.
• Neuroscience. 2014 Apr 18;265:21-7.

AbstractOrbitofrontal reality filtering denotes a memory control mechanism necessary to keep thought and behavior in phase with reality. Its failure induces reality confusion as evident in confabulation and disorientation. In the present study, we explored the influence of orbitofrontal transcranial direct current stimulation (tDCS) on reality filtering. Twenty healthy human subjects made a reality filtering task, while receiving cathodal, anodal, or sham stimulation over the frontal pole in three sessions separated by at least 1week. Computational models predicted that this montage can produce polarity-specific current flow across the posterior medial orbitofrontal cortex (OFC). In agreement with our hypothesis, we found that cathodal tDCS over the frontal pole specifically impaired reality filtering in comparison to anodal and sham stimulation. This study shows that reality filtering, an orbitofrontal function, can be modulated with tDCS.Copyright © 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

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