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- Hélèna L Denis, Jérôme Lamontagne-Proulx, Isabelle St-Amour, Sarah L Mason, Jesse W Rowley, Nathalie Cloutier, Marie-Ève Tremblay, Antony T Vincent, Peter V Gould, Sylvain Chouinard, Andrew S Weyrich, Matthew T Rondina, Roger A Barker, Eric Boilard, and Francesca Cicchetti.
- Centre de Recherche du CHU de Québec, Québec, QC, Canada.
- J. Neurol. Neurosurg. Psychiatr. 2019 Mar 1; 90 (3): 272-283.
AbstractHuntington's disease (HD) is a hereditary disorder that typically manifests in adulthood with a combination of motor, cognitive and psychiatric problems. The pathology is caused by a mutation in the huntingtin gene which results in the production of an abnormal protein, mutant huntingtin (mHtt). This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage.© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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