• Yasmine C Torres, Soniza V Alves-Leon, and Marco A Lima.
• Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
• World Neurosurg. 2019 Oct 1; 130: e333-e337.

BackgroundBrain tumors are frequent in clinical practice and associated with high morbidity and mortality. However, many diseases can present as tumefactive lesions and mimic neoplastic lesions. We aimed to determine the frequency of pseudotumoral central nervous system lesions referred to an oncology center and the frequency of the tumor mimickers.MethodsThis was a retrospective study at the National Institute of Cancer, Rio de Janeiro, Brazil. Medical charts of patients admitted to the Neurosurgery and Pediatrics services from 2007 to 2011 were reviewed. Clinical and radiologic features of cases initially diagnosed with primary central nervous system tumors but received a final diagnosis of pseudotumoral disease were recorded.ResultsAmong 891 patients referred as primary brain tumors, 38 cases had pseudotumoral lesions (4.3%). Most were adults (63%), with mean age of 29.4 years, and women (60.5%). Most frequent symptoms were headache (28.9%), motor signs (23.7%), and seizures (15.8%). Mean time from initial symptoms to diagnosis was 12.2 months. Lesions were single in 84.2% of patients, had contrast enhancement in 45.6%, and surrounding edema in 17.4%. Twenty patients (52,6%) underwent biopsy. Systemic autoimmune diseases were the most frequent etiologies (28.9%), followed by idiopathic inflammatory demyelinating diseases, infections, and vascular abnormalities (15.8% each). Good outcome with no major deficits was observed in 60.5% cases.ConclusionsThe frequency of pseudotumoral lesions in an oncology reference center was low. Young women were most affected, and lesions were associated more frequently with systemic autoimmune diseases. Prompt recognition is important to avoid unnecessary treatment, because most patients had a good outcome.Copyright © 2019 Elsevier Inc. All rights reserved.

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