• Anusha S Bhatt, Vikram Muthusubramanian, Asokan Kondappan, and Anita Mahadevan.
• Department of Neuropathology, National Institute of Mental Health and Neurosciences, Bengaluru, India.
• World Neurosurg. 2019 Oct 1; 130: 479-483.

BackgroundVascular tumors of the spine range from benign hemangiomas to malignant angiosarcomas. Hemangioendotheliomas of spine are tumors of intermediate-grade malignancy with rare occurrence in the intradural location. The imaging and histopathologic features may mimic other common lesions occurring at this location.Case DescriptionA 70-year-old woman presented with lower limb weakness and sensory impairment along the L5-S1 dermatome. A radiologic diagnosis of neurofibroma at the intradural location of the L4-L5 level was made, and total excision of the space-occupying lesion was done. Histopathologic examination, however, revealed a vascular tumor consistent with hemangioendothelioma, which was confirmed by immunohistochemical analysis. We present this case discussing the dilemmas and difficulties in arriving at the diagnosis, highlighting the role of immunohistochemical aid.ConclusionHistomorphology, aided by ancillar tests like immunohistochemistry, remains the criterion for the definitive diagnosis of such rare lesions, and pathologists need to be aware of these lesions occurring in uncommon locations.Copyright © 2019 Elsevier Inc. All rights reserved.

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