• Neuroscience · Aug 2019

    Neonatal Monosodium Glutamate Administration Disrupts Place Learning and Alters Hippocampal-Prefrontal Learning-Related Theta Activity in the Adult Rat.

    • Miguel Ángel López-Vázquez, Carla Estefanía Gama-García, Yoana Estrada-Reyes, Lorena Gaytán-Tocavén, José Miguel Cervantes Alfaro, and María Esther Olvera-Cortés.
    • Laboratorio de Neuroplasticidad de los Procesos Cognitivos, División de Neurociencias, Centro de Investigación Biomédica de Michoacán, Instituto Mexicano del Seguro Social, Camino de la Arboleda 300, Ex-Hacienda de San José de la Huerta, C.P., 58341, Morelia, Michoacán, México. Electronic address: miguel.lopezv@imss.gob.mx.
    • Neuroscience. 2019 Aug 21; 414: 228-244.

    AbstractNeonatal treatment with monosodium glutamate causes profound deficits in place learning and memory in adult rats evaluated in the Morris maze. Theta activity has been related to hippocampal learning, and increased high-frequency theta activity occurs through efficient place learning training in the Morris maze. We wondered whether the place learning deficits observed in adult rats that had been neonatally treated with monosodium glutamate (MSG), were related to altered theta patterns in the hippocampus and prelimbic cortex, which were recorded during place learning training in the Morris maze. The MSG-treated group had a profound deficit in place learning ability, with a marginal reduction in escape latencies during the final days of training. Learning-related changes were observed in the relative power distribution in control and MSG-treated groups in the hippocampal EEG, but not in the prelimbic cortex. Increased prefrontal and reduced hippocampal absolute power that appeared principally during the final days of training, and reduced coherence between regions throughout the training (4-12 Hz), were observed in the MSG-treated rats, thereby suggesting a misfunction of the circuits rather than a hyperexcitable general state. In conclusion, neonatal administration of MSG, which caused a profound deficit in place learning at the adult age, also altered the theta pattern both in the hippocampus and prelimbic cortex.Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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