• Magdalena Zaniewska, Dawid Gawliński, Maria Wyczesana, Ewa Nowak, Karol Kula, Martyna Maciów-Głąb, Joanna Jastrzębska, Anna Sadakierska-Chudy, Michael Bader, and Kjell Fuxe.
• Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Drug Addiction Pharmacology, 31-343 Kraków, 12 Smętna street, Poland; Maj Institute of Pharmacology, Polish Academy of Sciences, Department of Pharmacology, Laboratory of Pharmacology and Brain Biostructure, 31-343 Kraków, 12 Smętna street, Poland. Electronic address: zaniew@if-pan.krakow.pl.
• Neuroscience. 2019 Oct 15; 418: 133-148.

AbstractPreclinical data indicate that ethanol produces behavioral effects that can be regulated by many neurotransmitters and neuromodulators like adenosine (A). The most important receptors with respect to the rewarding effects of ethanol seem to be the A2A receptors. This study used a transgenic strategy, specifically rats overexpressing the A2A receptor, to characterize the neurobiological mechanisms of ethanol consumption as measured by intermittent access to 20% ethanol in a two-bottle choice paradigm. In this model, no change in ethanol consumption was observed in transgenic animals compared to wild type controls during the acquisition/maintenance phase. Following alcohol deprivation, only transgenic rats overexpressing the A2A receptor exhibited escalation of ethanol consumption and drank more (by ca. 90%), but not significantly, ethanol than did the wild type rats. During ethanol withdrawal, the immobility time of rats overexpressing the A2A receptor in the forced swim test was lower than that of wild type rats. Moreover, transgenic rats withdrawn from ethanol, compared to the drug-naive transgenic animals, exhibited an increase above 70% in locomotion. The results indicated that the overexpression of A2A receptors may be a risk factor for the escalation of ethanol consumption despite the reduction in depression-like signs of ethanol withdrawal.Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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