• J Neuroimaging · Jul 2012

    Case Reports

    Brain imaging in cerebellar ataxia associated with autoimmune polyglandular syndrome type 2.

    • Mario Manto and P Jissendi.
    • Department of Neurology, Hôpital Erasme-ULB, Brussels, Belgium. mmanto@ulb.ac.be
    • J Neuroimaging. 2012 Jul 1;22(3):308-11.

    AbstractAutoimmune polyglandular syndrome (APS) type 2 (Schmidt syndrome) is a disorder characterized by a combination of autoimmune adrenal insufficiency, autoimmune thyroid disease, and type 1 autoimmune diabetes mellitus. We describe the first case of subacute cerebellar syndrome associated with APS type 2. Brain magnetic resonance imaging showed atrophy of the cerebellum and the vermis, as well as of the anterior pituitary gland. Magnetic resonance spectroscopy showed decreased N-acetylaspartate/creatine ratio in the cerebellum and in the pons. Our findings expand the spectrum of neurological deficits in APS type 2 and underlines that cerebellar pathways may be a main target of the disorder.© 2010 by the American Society of Neuroimaging.

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