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- Y-Y Zhu, L Jing, T-T Duan, Q Yuan, J Cao, Q-X Zhou, and L Xu.
- Key Laboratory of Animal Models and Human Disease Mechanisms and Laboratory of Learning and Memory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
- Neuroscience. 2013 Oct 10;250:658-63.
AbstractCertain patterns of neural activity can induce N-methyl-D-aspartic acid receptor (NMDAR)-dependent synaptic plasticity, one of the important foundations of memory. Here, we report that a patterned high-frequency stimulation (PHS) induces rat hippocampal long-term depression (LTD) in an NMDAR-independent manner that requires coactivation of GABA(A)Rs and muscarinic acetylcholine receptors (mAChRs), and endocytosis of AMPARs. Thus, we disclose that a patterned high-frequency stimulation triggers GABAAR and mAChR-dependent LTD in the hippocampus.Copyright © 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
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