• Lavinia Dinia, Laura Bonzano, Beatrice Albano, Cinzia Finocchi, Massimo Del Sette, Laura Saitta, Lucio Castellan, Carlo Gandolfo, and Luca Roccatagliata.
• Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, Genoa, Italy.
• J Neuroimaging. 2013 Jan 1;23(1):47-52.

ObjectiveTo prospectively evaluate longitudinal changes in white matter lesions (WMLs) in migraineurs with aura, by magnetic resonance imaging (MRI), and to correlate WMLs modifications with patients' clinical characteristics.MethodsForty-one consecutive migraineurs with aura were followed for a mean time of 33.2 months. Patients underwent MRI at baseline and follow-up and were evaluated for cerebrovascular risk factors. Presence of WMLs on MRI was assessed by two neuroradiologists.ResultsWMLs were present in 26 subjects (63.4%) at baseline MRI. At follow-up a total of 8 patients had new WMLs (19.5%). There was a significant correlation between aura duration and number of new WMLs, and between the number of migraine attacks with aura and new WMLs.ConclusionsOur study demonstrates that in migraine with aura WMLs number can progress over time and suggests an association between aura features and WMLs progression. Studies with a higher number of patients are required to confirm these findings.Copyright © 2012 by the American Society of Neuroimaging.

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