• Yuji Suzuki, Yukihiro Nakamura, Kenichi Yamada, Vincent J Huber, Mika Tsujita, and Tsutomu Nakada.
• Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata.
• J Neuroimaging. 2013 Apr 1;23(2):219-23.

Background And PurposeAquaporin 4 (AQP-4) is the most abundant aquaporin isoform in the brain. Alterations in its expression and distribution have been correlated with the progression of several clinical disorders; however, the specific roles of AQP-4 in those disorders are not well understood. Visualizing AQP-4 in vivo is expected to provide fresh insights into its roles in disease pathology, as well as aiding the clinical assessment of those disorders.MethodsWe developed a 11C-labeled analogue of the AQP-4 ligand TGN-020 (2-nicotinamido-1,3,4-thiadiazole) suitable for in vivo positron emission tomography (PET) imaging.ResultsIn the present study, we report the first PET images of AQP-4 in the human brain. The results unequivocally demonstrated a specific distribution pattern for AQP-4 within the brain, namely, the subpial and perivascular endfeet of astrocytes. The choroid plexus, where both AQP-4 and AQP-1 are expressed, also showed substantial uptake of the ligand.ConclusionsBased on these initial results, we believe [11C]TGN-020 PET will be valuable in determining the role of AQP-4 in disease progression, and for the clinical assessment of water homeostasis under various settings.Copyright © 2012 by the American Society of Neuroimaging.

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