• J Neuroimaging · Jan 2016

    Impact of Apolipoprotein E4 Polymorphism on the Gray Matter Volume and the White Matter Integrity in Subjective Memory Impairment without White Matter Hyperintensities: Voxel-Based Morphometry and Tract-Based Spatial Statistics Study under 3-Tesla MRI.

    • Young-Min Lee, Ji-Kyung Ha, Je-Min Park, Byung-Dae Lee, EunSoo Moon, Young-In Chung, Ji-Hoon Kim, Hak-Jin Kim, Chi-Woong Mun, Tae-Hyung Kim, and Young-Hoon Kim.
    • Department of Psychiatry, Pusan National University School of Medicine, Busan, Korea.
    • J Neuroimaging. 2016 Jan 1; 26 (1): 144-9.

    ObjectiveThe aim of this study is to compare gray matter (GM) volume and white matter (WM) integrity in Apolipoprotein E4 (ApoE ε4) carriers with that of ApoE ε4 noncarriers using the voxel-based morphometry and diffusion tensor imaging (DTI) to investigate the effect of the ApoE ε4 on brain structures in subjective memory impairment (SMI) without white matter hyperintensities (WMH).MethodsAltogether, 26 participants with SMI without WMH were finally recruited from the Memory impairment clinics of Pusan National University Hospital in Korea. All participants were ApoE genotyped (ApoE ε4 carriers: n = 13, matched ApoE ε4 noncarriers: n = 13) and underwent 3-tesla magnetic resonance imaging (MRI) including 3-dimensional volumetric images for GM volume and DTI for WM integrity.ResultsApoE ε4 carriers compared with noncarriers in SMI without WMH showed the atrophy of GM in inferior temporal gyrus, inferior parietal lobule, anterior cingulum, middle frontal gyrus, and precentral gyrus and significantly lower fractional anisotropy WM values in the splenium of corpus callosum and anterior corona radiate.ConclusionOur findings suggest that the ApoE ε4 is associated with both atrophy of GM volume and disruption of WM integrity in SMI without WMH.Copyright © 2015 by the American Society of Neuroimaging.

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