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- Sheraz R Markar, Sung-Tong Chin, Andrea Romano, Tom Wiggins, Stefan Antonowicz, Paraskevas Paraskeva, Paul Ziprin, Ara Darzi, and George B Hanna.
- Department of Surgery and Cancer, Imperial College London, London, UK.
- Ann. Surg. 2019 May 1; 269 (5): 903-910.
ObjectiveBACKGROUND:: Breath VOCs have the potential to noninvasively diagnose cancer.MethodsExhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS:: CONCLUSION:: This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.
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