• Gerhard Opelz, Caner Süsal, Andrea Ruhenstroth, and Bernd Döhler.
• Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. gerhard.opelz@med.uni-heidelberg.de
• Transplantation. 2010 Oct 27; 90 (8): 912-7.

BackgroundData concerning the impact of human leukocyte antigen (HLA) compatibility on lung transplant survival rates are limited.MethodsUsing the Collaborative Transplant Study database, 5-year graft outcome according to HLA mismatch was examined in 8020 deceased donor lung transplants performed during 1989 to 2009.ResultsGraft survival rates showed a stepwise decrease as the combined number of HLA-A+B+DR mismatches increased from one to six (P<0.001). Surprisingly, the 28 grafts with 0 mismatches at all 3 loci had a 1-year survival rate of only 49.7%, significantly lower than for 1, 2, 3, 4, 5, or 6 mismatches (P=0.002, <0.001, <0.001, <0.001, 0.002, and 0.003, respectively). Multivariate regression analysis confirmed that, paradoxically, transplantation of grafts with zero HLA-A+B+DR mismatches was associated with a 19% increase in relative risk of failure. Donor lung preservation for up to 12 hr was not associated with inferior graft survival versus shorter preservation times (P=0.60).ConclusionsOur data show that a high number of HLA mismatches or zero mismatches impacts unfavorably on lung transplant survival.

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