Transplantation
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Multicenter Study
Impact of HLA compatibility on lung transplant survival and evidence for an HLA restriction phenomenon: a collaborative transplant study report.
Data concerning the impact of human leukocyte antigen (HLA) compatibility on lung transplant survival rates are limited. ⋯ Our data show that a high number of HLA mismatches or zero mismatches impacts unfavorably on lung transplant survival.
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Organ shortage is responsible for high mortality rates of patients awaiting liver transplantation (LT). Domino transplantation has had reported success in patients with metabolic disorders. Primary hyperoxaluria type 1 (PH1) is a rare metabolic disorder. There are a few case reports that suggest that PH1 livers originating from donors that have undergone combined liver-kidney transplantation can be successfully used for domino transplantation. ⋯ Domino LT using donors with PH1 results in early renal failure and cannot be recommended for transplantation unless preventive strategies have been identified.