• Nichol M L Wong, Robin Shao, Patcy P S Yeung, Pek-Lan Khong, Edward S Hui, C Mary Schooling, Gabriel M Leung, and Lee Tatia M C TMC State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Laboratory of Neuropsychology, The University of Hong Kong.
• State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong; Laboratory of Neuropsychology, The University of Hong Kong, Hong Kong; Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom.
• Neuroscience. 2019 Nov 21; 421: 39-47.

AbstractLoneliness has a strong neurobiological basis reflected by its specific relationships with structural brain connectivity. Critically, affect traits are highly related to loneliness, which shows close association with the onset and severity of major depressive disorder. This diffusion imaging study was conducted on a sample of adolescent siblings to examine whether positive and negative affect traits were related to loneliness, with brain network efficiency playing a mediating role. The findings of this study confirmed that both global and average local efficiency negatively mediated the association between low positive affect and high negative affect and loneliness, and the mediation was more sensitive to sibling-shared affect traits. The findings have important implications for interventions targeted at reducing the detrimental impact of familiar negative emotional experiences and loneliness.Copyright © 2019 IBRO. Published by Elsevier Ltd. All rights reserved.

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