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- Jun Ma, John Williams, Derek Eastwood, Siyu Lin, Xiaoyan Qian, Qiwu Fang, Doris Cope, Zengqiang Yuan, Liu Cao, and Jianxiong An.
- Department of Anesthesiology, Pain Medicine & CCM, Aviation General Hospital of China Medical University & Beijing Institute of Translational Medicine, Chinese Academy of Sciences, Beijing, China; Laboratory of Medical Cell Biology, College of Translational Medicine, China Medical University, Shenyang, China.
- Neuroscience. 2019 Nov 21; 421: 136-143.
AbstractPostoperative cognitive dysfunction (POCD) is a common postoperative complication observed in patients following. Here we tested the molecular mechanisms of memory loss in hippocampus of rat POCD model. We found that high-dose propofol anesthesia significantly alleviated spatial memory loss. The proteomes and transcriptomes in hippocampus showed that hippocampal cytoskeleton related pathways were abnormal in low group while not in high group. The protein assays confirmed that hippocampal actin cytoskeleton was depolymerized in low group while maintained in high group. This study confirms that high-dose propofol anesthesia could mitigate the development of POCD and provides evidences for actin cytoskeleton associated with this syndrome.Copyright © 2019. Published by Elsevier Ltd.
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