• Neuroscience · Aug 2012

    Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization.

    • Y Xu, Lingling Qian, Guijuan Zong, K Ma, X Zhu, H Zhang, N Li, Q Yang, H Bai, J Ben, X Li, and Q Chen.
    • Atherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing 210029, China.
    • Neuroscience. 2012 Aug 30;218:35-48.

    AbstractClass A scavenger receptor (SR-A) is primarily expressed in microglia/macrophages and plays an important role in immune responses. However, whether SR-A can influence microglia/macrophage polarization in cerebral ischemic injury is not known. To this end we monitored the phenotypic alteration of microglia/macrophages in an animal model of cerebral ischemia injury. SR-A was up-regulated in mouse brains 24h after permanent occlusion of middle cerebral artery (MCAO). SR-A-deficient mice displayed reduced infarct size and improved neurological function compared with wild-type mice littermate controls. Furthermore, a decrease in inflammatory F4/80(+)CD11b(+)CD45(high)CD11c(+) microglia/macrophages and attenuated nuclear factor-kappaB (NF-κB) activation was found in ischemic brains in the SR-A null mice. This was accompanied by alleviation of classically activated M1 macrophage markers and preservation of alternatively activated M2 macrophage markers. These data suggest that SR-A contributes to cerebral ischemic injury by pivoting the phenotype of microglia/macrophages to a skewed M1 polarization.Copyright © 2012 IBRO. Published by Elsevier Ltd. All rights reserved.

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