• Neuroscience · Apr 2020

    Chronic infiltration of T lymphocytes into the brain in a non-human primate model of Parkinson's disease.

    • Jincheol Seo, Junghyung Park, Keonwoo Kim, Jinyoung Won, Hyeon-Gu Yeo, Yeung Bae Jin, Bon-Sang Koo, Kyung Seob Lim, Kang-Jin Jeong, Philyong Kang, Hwal-Yong Lee, Won Seok Choi, Seung Ho Baek, Chang-Yeop Jeon, Jung-Joo Hong, Jae-Won Huh, Young-Hyun Kim, Sang Je Park, Sun-Uk Kim, Dong-Seok Lee, Sang-Rae Lee, and Youngjeon Lee.
    • National Primate Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, Republic of Korea; School of Life Sciences, BK21 Plus KNU Creative BioResearch Group, Kyungpook National University, Daegu 41566, Republic of Korea.
    • Neuroscience. 2020 Apr 1; 431: 73-85.

    AbstractStudy of interactions between the nervous system and immunity offers insights into the pathogenesis of Parkinson's disease (PD) and potential therapeutic strategies for neurodegenerative diseases. Studies on rodents have revealed regulatory mechanisms of microglial activation and T lymphocyte recruitment in PD. However, the mechanisms underlying chronic T lymphocyte infiltration into the brain after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injection into a non-human primate (NHP) model of PD remain unknown. This study aimed to investigate changes in serum RANTES (regulated on activation, normal T cell expression and secretion) and analyze the chronic infiltration of T lymphocytes into the brain and microglia activation in NHPs at 48 weeks post-MPTP administration. We found selective and local chronic infiltration of CD4+ and CD8+ T lymphocytes, loss of dopaminergic neurons, dopamine transporter expression, chronic normalization of RANTES in the peripheral blood, and altered microglial morphology at 48 weeks after MPTP injection. This study confirms the involvement of CD4+ and CD8+ T lymphocyte infiltration in MPTP-induced NHP models of PD. Additionally, we corroborated previous findings regarding the mechanisms of T lymphocyte-induced neurodegeneration. The findings of chronic infiltration of T lymphocytes in our NHP model of PD provide novel insights into PD pathogenesis and the development of preventive and therapeutic agents.Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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