• World Neurosurg · Jul 2020

    Development of an experimental model for studying the nasosinusal and skull base arterial and venous systems using iodinated contrast and latex in cadavers.

    • Livia Castellari Burchianti, Dolci Ricardo Landini Lutaif RLL Department of Otorhinolaryngology, Irmandade da Santa Casa de Misericórdia de São Paulo, Santa Casa de Sao Paulo School of Medical Scienc, de Souza Jamile Lopes JL Department of Otorhinolaryngology, Irmandade da Santa Casa de Misericórdia de São Paulo, Santa Casa de Sao Paulo School of Medical Sciences, São , Henrique Bortot Zuppani, Lucas Carvalho Santos, Lucas Araújo Mendes, Mirna Duarte Barros, Mendes Carlos José Lazzarini CJL Department of Morphology, Santa Casa de Sao Paulo School of Medical Sciences, São Paulo/SP, Brasil., Dos Santos Américo Rubens Leite ARL Neurosurgery Discipline, Department of Surgery, Irmandade da Santa Casa de Misericórdia de São Paulo, Santa Casa de Sao Paulo School o, and Paulo Roberto Lazarini.
    • Department of Otorhinolaryngology, Irmandade da Santa Casa de Misericórdia de São Paulo, Santa Casa de Sao Paulo School of Medical Sciences, São Paulo/SP, Brasil. Electronic address: liliburch@hotmail.com.
    • World Neurosurg. 2020 Jul 1; 139: e98-e112.

    BackgroundCadaver dissection remains one of the most reliable and safest ways to study anatomy, whereas computed tomography angiography (CTA) is an essential technology for enabling students to become familiar with human anatomy and surgical planning. Thus, the convergence of both radiologic and anatomic information is important for surgical success, especially in regions of complex anatomy such as the nasosinusal and skull base regions. Here we propose an experimental model in formalinized cadaver heads consisting of intravascular injection of colored latex and iodinated contrast mixture, followed by CTA scans of the nasosinusal and skull base arterial and venous systems before dissection.MethodsSix cadaver heads that had been preserved for >5 years in 10% formaldehyde were immersed for 72 hours in a solution containing a dimethyldiethanol mono/dialkyloyl ester quaternary ammonium salt. In 5 of these heads, a mixture composed of latex, tissue ink, and iodinated contrast (Ultravist 300) was injected into the vascular system. CTA scans were performed sequentially after the injection, followed by endonasal and macroscopic dissections.ResultsThere was good radiologic and macroscopic vessel uptake in 4 specimens, allowing a detailed anatomic study.ConclusionsAn experimental model was made feasible by injecting iodinated contrast and colored latex into formalinized cadavers for CTA evaluation of the nasosinusal and skull base arterial and venous systems before performing dissections.Copyright © 2020 Elsevier Inc. All rights reserved.

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