• Lukas Frase, Friederike Jahn, Sulamith Tsodor, Lukas Krone, Peter Selhausen, Bernd Feige, Jonathan G Maier, Hannah Piosczyk, Dieter Riemann, Michael A Nitsche, and Christoph Nissen.
• Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Freiburg, Germany.
• Neuromodulation. 2021 Jul 1; 24 (5): 910-915.

ObjectivesA proposed replay of memory traces between the hippocampus and frontal cortical brain areas during sleep is of high relevance for overnight memory consolidation. Recently, we demonstrated that bi-frontal anodal transcranial direct current stimulation (tDCS) prior to sleep increases waking EEG gamma power and decreases total sleep time during the night. It is unclear whether this effect on cortical excitability has an influence on overnight memory consolidation. We hypothesized that bi-frontal evening tDCS interferes with overnight memory consolidation with a polarity specific impairment following anodal tDCS.Materials And MethodsNineteen healthy participants underwent a within-subject, repeated-measures protocol in the sleep laboratory with bi-frontal tDCS applied prior to sleep according to the experimental protocol (anodal, cathodal, sham stimulation). Memory tasks for declarative and procedural memory were assessed prior to tDCS and on the following morning.ResultsNo deterioration of overnight memory consolidation following evening offline bi-frontal tDCS could be detected.Conclusion(S)The application of tDCS can be considered safe regarding overnight memory consolidation and represents a promising treatment approach in conditions of decreased vigilance and arousal.© 2020 The Authors. Neuromodulation: Technology at the Neural Interface published by Wiley Periodicals LLC. on behalf of International Neuromodulation Society.

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