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- Li-Da Su, Fang-Xiao Xu, Xin-Tai Wang, Xin-Yu Cai, and Ying Shen.
- Neuroscience Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
- Neuroscience. 2021 May 10; 462: 320-327.
AbstractThe cerebellum has long been conceptualized to control motor learning and motor coordination. However, increasing evidence suggests its roles in cognition and emotion behaviors. In particular, the cerebellum has been recognized as one of key brain regions affected in autism spectrum disorder (ASD). To better understand the contribution of the cerebellum in ASD pathogenesis, we here discuss recent behavioral, genetic, and molecular studies from the human and mouse models. In addition, we raise several questions that need to be investigated in future studies from the point view of cerebellar dysfunction, cerebro-cerebellar connectivity and ASD.Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.
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