• Dan Wen, Xin Du, Jian-Zeng Dong, and Chang-Sheng Ma.
• Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 Anzhen Road, Chaoyang District, Beijing 100029, China.
• Eur. J. Intern. Med. 2019 May 1; 63: 69-73.

BackgroundA few recent studies have demonstrated that hepatitis C virus (HCV) infection was associated with coronary artery diseases (CAD). However, there still existed studies did not confirm this correlation.ObjectiveThe objective of this study was to evaluate the association between HCV infection and CAD using a meta-analysis.MethodsPubmed, Embase, and Cochrane library databases were systemically searched. Data were extracted by two independent reviewers and pooled odds ratio (OR) and relative risk (RR) with 95% confidence interval (CI) were calculated using the fixed and random effects models.ResultsEight cohort studies and six case-control and cross-sectional studies were enrolled in this meta-analysis. In the cohort studies, the overall RR and 95% CIs of HCV infection for CAD was 1.25, 1.12-1.40 in random effects model. For the case-control and cross-sectional studies, the overall OR and 95% CIs of HCV infection for CAD were 1.94, 1.58-2.38 in fixed effects model. No publication bias was found in this meta-analysis.ConclusionsThis meta-analysis showed that HCV infection was a risk factor for CAD.Copyright © 2019 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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