The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
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J. Matern. Fetal. Neonatal. Med. · Jan 2016
Review Meta AnalysisCarbetocin for the prevention of postpartum hemorrhage: a systematic review and meta-analysis of randomized controlled trials.
To compare the efficacy and safety profile of carbetocin with other uterotonic agents in preventing postpartum hemorrhage. ⋯ Carbetocin has been associated with a similar low incidence of adverse effects to oxytocin and at least as effective as syntometrine and may become an alternative uterotonic agent for the prevention of postpartum hemorrhage. Further studies should be conducted to determine the safety and efficacy profile of carbetocin in women with cardiac disorders and to analyze the cost-effectiveness and minimum effective dose of carbetocin.