Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · Nov 2017
Multicenter Study Observational StudyClinical course of patients with symptomatic isolated superficial vein thrombosis: the ICARO follow-up study.
Essentials Late sequelae of isolated superficial vein thrombosis (iSVT) have rarely been investigated. We studied 411 consecutive outpatients with acute iSVT with a median follow-up of three years. Male sex and cancer are risk factors for future deep vein thrombosis or pulmonary embolism. Patients without cancer appear to be at a negligible risk for death.
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J. Thromb. Haemost. · Nov 2017
Randomized Controlled Trial Multicenter Study Comparative StudyEffect of late prophylaxis in hemophilia on joint status: a randomized trial.
Essentials High-quality data are lacking on use of prophylaxis in adults with hemophilia and arthropathy. SPINART was a 3-year randomized clinical trial of late/tertiary prophylaxis vs on-demand therapy. Prophylaxis improved function, quality of life, activity and pain but not joint structure by MRI. Prophylaxis improves function but must start before joint bleeding onset to prevent arthropathy.