Journal of thrombosis and haemostasis : JTH
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J. Thromb. Haemost. · May 2018
Multicenter Study Observational StudyLow drug levels and thrombotic complications in high-risk atrial fibrillation patients treated with direct oral anticoagulants.
Essentials Direct oral anticoagulants (DOACs) do not require laboratory monitoring currently. DOAC specific measurements were performed at trough in patients with atrial fibrillation. Patients who developed thromboembolic events showed lower DOAC plasma levels. This study supports the concept of measuring DOAC levels at steady state.