The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutical Chemistry and Biology
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Q J Nucl Med Mol Imaging · Dec 2007
S-factor calculations for mouse models using Monte-Carlo simulations.
Targeted radionuclide therapy applications require the use of small animals for preclinical experiments. Accurate dose estimation is needed in such animals to explore and analyze the toxicity of injected radiopharmaceuticals. We developed two numerical models to allow for a more accurate mouse dosimetry. ⋯ The voxel-based models represent more realistic anatomic approach. The rapid advancement of computer science and new features added to Monte-Carlo codes permit considerable reduction of computational run time. Cross-doses should not be neglected when medium to high energy beta emitters are being used for preclinical experiments on mice.