Chest
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Randomized Controlled Trial Clinical Trial
A phase I trial of intranasal Moli1901 for cystic fibrosis.
The peptide drug Moli1901 activates an alternative chloride channel that is present in cystic fibrosis (CF) nasal and airway epithelia. Doing so bypasses the dysfunctional CF transmembrane regulator. ⋯ Moli1901 stimulates chloride transport in normal and CF nasal epithelia in vivo, but may have a shorter duration of action in CF participants.
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Randomized Controlled Trial Clinical Trial
The efficacy of premixed nitrous oxide and oxygen for fiberoptic bronchoscopy in pediatric patients: a randomized, double-blind, controlled study.
s: The aim of the study was to evaluate the efficacy and safety of premixed 50% nitrous oxide and oxygen on the quality of sedation and pain control during fiberoptic bronchoscopy (FB) in children. ⋯ This study demonstrates the improved efficacy of sedation, pain control, and safety of premixed 50% nitrous oxide and oxygen for FB in children.
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Randomized Controlled Trial Comparative Study Clinical Trial
Effect of three wound dressings on infection, healing comfort, and cost in patients with sternotomy wounds: a randomized trial.
To compare three dressing types in terms of their ability to protect against infection and promote healing, patient comfort, and cost-effectiveness. ⋯ In the context of no additional benefit for the prevention of wound infection or the rate of wound healing for any of the three dressing products examined, dry absorbent dressings are the most comfortable and cost-effective products for sternotomy wounds following cardiac surgery.