Postgraduate medical journal
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Multilevel cervical spondylotic myelopathy (CSM) and ossification of the posterior longitudinal ligament (OPLL) are debilitating degenerative diseases. If conservative treatment is ineffective, surgical options for multilevel CSM and OPLL include laminoplasty (LP) and laminectomy with fusion (LF). In this updated meta-analysis, we aimed to compare the clinical outcomes and complications of both approaches. ⋯ Although LP and LF shared similar clinical improvement, LP had fewer complications, a lower incidence of C5 palsy, and better NDI scores and recovery outcomes than LF. Randomised studies are warranted to validate these findings.
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Meta Analysis
Different pedagogies for acquisition of knowledge and skill: a systematic review and network meta-analysis.
This network meta-analysis aimed to assess the efficacy of different educational methods for healthcare professionals. ⋯ Our study demonstrates all educational methods have positive effects on knowledge acquisition, but education methods involving high fidelity virtual patient simulation are better at improving skill performance than other methods.
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Statin use is associated with decreased COVID mortality.
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Meta Analysis Controlled Clinical Trial
Sofosbuvir with daclatasvir and the outcomes of patients with COVID-19: a systematic review and meta-analysis with GRADE assessment.
This systematic review and meta-analysis aimed to evaluate the effect of sofosbuvir/daclatasvir (SOF/DCV) on mortality, the need for intensive care unit (ICU) admission or invasive mechanical ventilation (IMV) and clinical recovery in patients with COVID-19. ⋯ PROSPERO: CRD42021247510.
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Meta Analysis
Prognostic value of elevated lactate dehydrogenase in patients with COVID-19: a systematic review and meta-analysis.
This meta-analysis aimed to evaluate the prognostic performance of elevated lactate dehydrogenase (LDH) in patients with COVID-19. ⋯ CRD42020221594.