The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · Aug 2009
Comparative StudyPrevalence of obstructive sleep apnea-hypopnea in severe versus moderate asthma.
Previous studies have suggested a link between obstructive sleep apnea and poor asthma control, which may be mediated through airway inflammation, obesity, and other mechanisms. ⋯ Obstructive sleep apnea-hypopnea was significantly more prevalent among patients with severe compared with moderate asthma, and more prevalent for both asthma groups than controls without asthma. These observations suggest potential pathophysiologic interactions between obstructive sleep apnea-hypopnea and asthma severity and control.
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J. Allergy Clin. Immunol. · Aug 2009
Exploring the repertoire of IgE-binding self-antigens associated with atopic eczema.
Atopic eczema (AE) is the most common chronic inflammatory skin disease. Recent data demonstrate the presence of autoreactive serum IgE antibodies correlating with the severity of the disease. ⋯ These data demonstrate a broad spectrum of at least 140 IgE-binding self-antigens associated with AE. By binding IgE antibodies or activating specific T cells, they might promote, perpetuate, or both existing skin inflammation.
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J. Allergy Clin. Immunol. · Aug 2009
Does higher body mass index contribute to worse asthma control in an urban population?
Epidemiologic findings support a positive association between asthma and obesity. ⋯ Using 4 validated asthma control questionnaires, we failed to find an association between obesity and asthma control in an urban population with asthma. Weight loss may not be an appropriate strategy to improve asthma control in this population.