The Journal of allergy and clinical immunology
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J. Allergy Clin. Immunol. · May 2014
Randomized Controlled Trial Multicenter StudyObesity and adiposity indicators, asthma, and atopy in Puerto Rican children.
Whether adiposity indicators other than body mass index (BMI) should be used in studies of childhood asthma is largely unknown. The role of atopy in "obese asthma" is also unclear. ⋯ Adiposity indicators are associated with asthma, asthma severity/control, and atopy in Puerto Rican children. Atopy significantly mediates the effect of adiposity on asthma outcomes. Longitudinal studies are needed to further investigate the causal role, if any, of adiposity distribution and atopy on "obese asthma" in childhood.
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J. Allergy Clin. Immunol. · May 2014
Multicenter Study Clinical TrialUnsupervised phenotyping of Severe Asthma Research Program participants using expanded lung data.
Previous studies have identified asthma phenotypes based on small numbers of clinical, physiologic, or inflammatory characteristics. However, no studies have used a wide range of variables using machine learning approaches. ⋯ The unsupervised machine learning approaches used here provide unique insights into disease, confirming other approaches while revealing novel additional phenotypes.
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J. Allergy Clin. Immunol. · May 2014
Multicenter Study Clinical TrialDetection of pathogenic bacteria during rhinovirus infection is associated with increased respiratory symptoms and asthma exacerbations.
Detection of either viral or bacterial pathogens is associated with wheezing in children; however, the influence of both bacteria and viruses on illness symptoms has not been described. ⋯ Rhinovirus infection enhances detection of specific bacterial pathogens in children with and without asthma. Furthermore, these findings suggest that M catarrhalis and S pneumoniae contribute to the severity of respiratory tract illnesses, including asthma exacerbations.