Anesthesiology
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Randomized Controlled Trial Multicenter Study Comparative Study
Titration of propofol for anesthetic induction and maintenance guided by the bispectral index: closed-loop versus manual control: a prospective, randomized, multicenter study.
This report describes a closed-loop titration of propofol target control infusion based on a proportional-differential algorithm guided by the Bispectral Index (BIS) allowing induction and maintenance of general anesthesia and compares this to manual propofol target control infusion. ⋯ Automatic control of consciousness using the BIS is clinically feasible and outperforms manual control.