Anesthesiology
-
The purpose of this study was to clarify the role of glutamate and reactive oxygen species in sevoflurane-mediated neuroprotection on an in vitro model of ischemia-reoxygenation. ⋯ Sevoflurane had a neuroprotective effect in this in vitro model of ischemia-reoxygenation. This beneficial effect may be explained, at least in part, by sevoflurane-induced antiexcitotoxic properties during OGD, probably depending on GLT1, and by sevoflurane-induced decrease of reactive oxygen species generation during reoxygenation.
-
New software was used during a pilot study of nonlinear changes in the electroencephalogram during emergence from sevoflurane anesthesia. ⋯ The dynamical stages of emergence from sevoflurane anesthesia into consciousness demonstrate a classic route toward chaos, but the presence of chaos in the conscious state remains unproven. These stages are apparent both pictorially and analytically. Pre-emergent attractor patterns are usually distinctive; their real-time display could be a useful adjunct to depth of anesthesia monitors because they may provide warning of an imminent return to consciousness.
-
The myocardial negative inotropic effects of desflurane are less pronounced than those of other halogenated anesthetics, partly because of intramyocardial catecholamine store release. However, the effects of desflurane on aging myocardium are unknown, whereas aging is known to be associated with an attenuation of catecholamine responsiveness. ⋯ The authors' study suggests that desflurane does not induce significant intramyocardial catecholamine release in senescent myocardium, a result that should be integrated in the well-known alteration in the catecholamine response during aging.
-
Comment Letter Randomized Controlled Trial
Ambesh maneuver during subclavian vein catheterization successfully prevents and detects misplacement of the catheter into ipsilateral internal jugular vein.