Anesthesiology
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Randomized Controlled Trial Multicenter Study Comparative Study
Phase 2, double-blind, placebo-controlled, dose-response trial of intravenous adenosine for perioperative analgesia.
Adenosine regulates pain transmission by actions at spinal, supraspinal, and peripheral sites. A few studies have suggested that administration of adenosine might be associated with anesthetic- and analgesic-sparing effects. The primary aim of this multicenter study was to determine the dose-response profile of adenosine with respect to perioperative analgesia. ⋯ There were no differences between placebo and adenosine with respect to efficacy and safety for perioperative analgesia.