Anesthesiology
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Randomized Controlled Trial Comparative Study
Quantitation of the effect of nitrous oxide on rocuronium infusion requirements using closed-loop feedback control.
Nitrous oxide has a minor effect on the effective dose 50% values of bolus doses of rocuronium. The authors have studied the effect of nitrous oxide on the infusion requirements of rocuronium using closed-loop feedback control of rocuronium infusion. ⋯ Nitrous oxide does not affect the infusion requirements of rocuronium to a clinically significant degree.
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Randomized Controlled Trial Comparative Study
Magnitude of the second gas effect on arterial sevoflurane partial pressure.
A number of studies have demonstrated a faster rate of increase in end-expired partial pressure as a fraction of inspired (Pa/Pi) for volatile agents in the presence of high concentrations of nitrous oxide, consistent with the second gas effect. However, no study has demonstrated a similar effect on arterial blood concentrations. ⋯ Nitrous oxide uptake exerts a significant second gas effect on arterial sevoflurane partial pressures. This effect is two to three times more powerful than the effect on end-expired partial pressures. The authors explain how this is due to the influence of ventilation-perfusion scatter on the distribution of blood flow and gas uptake in the lung.