Anesthesiology
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Multicenter Study Comparative Study
Development of the functional recovery index for ambulatory surgery and anesthesia.
It is increasingly important to evaluate patients' recovery after ambulatory surgery. The authors developed the Functional Recovery Index (FRI) to assess postdischarge functional recovery for ambulatory surgical patients. ⋯ The FRI had excellent reliability, good validity, responsiveness, and acceptability, indicating that this questionnaire will be a good instrument for assessing functional recovery of ambulatory surgical patients.
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Comparative Study
Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon.
The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. ⋯ Goal-directed colloid fluid therapy significantly increased microcirculatory blood flow and tissue oxygen tension in healthy and injured colon compared to goal-directed or restricted crystalloid fluid therapy.
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Comparative Study
Development and validation of an acute kidney injury risk index for patients undergoing general surgery: results from a national data set.
The authors sought to identify the incidence, risk factors, and mortality impact of acute kidney injury (AKI) after general surgery using a large and representative national clinical data set. ⋯ Approximately 1% of general surgery cases are complicated by AKI. The authors have developed a robust risk index based on easily identified preoperative comorbidities and patient characteristics.
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Comparative Study
Strict glucose control does not affect mortality after aneurysmal subarachnoid hemorrhage.
The effects of both hyperglycemia and hypoglycemia are deleterious to patients with neurologic injury. ⋯ The initiation of a tight glucose control regimen lowered average glucose levels but had no effect on overall in-hospital mortality.
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Comparative Study
Assessment of postischemic neurogenesis in rats with cerebral ischemia and propofol anesthesia.
Postischemic endogenous neurogenesis can be dose-dependently modulated by volatile anesthetics. The intravenous anesthetic propofol is used during operations with a risk of cerebral ischemia, such as neurosurgery, cardiac surgery, and vascular surgery. The effects of propofol on neurogenesis are unknown and, therefore, the object of this study. ⋯ Independent effects of propofol are difficult to ascertain. Peri-ischemic propofol administration may exert secondary effects on neurogenesis by modulating the severity of histopathologic injury and thereby regenerative capacity of the hippocampus.