Anesthesiology
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Randomized Controlled Trial
Lumbar sympathetic blockade in children with complex regional pain syndromes: a double blind placebo-controlled crossover trial.
Sympathetic blockade is used in the management of complex regional pain syndromes in children, but there are no data on the efficacy or mechanism(s) by which it produces pain relief. The purpose of this study is to compare the efficacy of lidocaine administered by lumbar sympathetic to IV route. ⋯ Under the conditions of this study, the results provide some direct evidence that a component of pain may be mediated by abnormal sympathetic efferent activity.
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Randomized Controlled Trial
General anesthesia increases temporal precision and decreases power of the brainstem auditory-evoked response-related segments of the electroencephalogram.
Brainstem auditory-evoked responses (BAEP) have been reported to be unchanged in the presence of drugs used for induction and maintenance of general anesthesia. The aim of this study was to investigate if the signal segments after the auditory stimulus that are used to average the evoked response change under the influence of general anesthesia. ⋯ General anesthesia affects phase and power of the segments of the electroencephalogram related to BAEP wave V. This study's results support the idea that temporally precise responses from a large number of neurons in the brainstem might play a crucial role in encoding and passing sensory information to higher subcortical and cortical areas of the brain.