Anesthesiology
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Perioperative cardiopulmonary arrests are uncommon and little is known about rates and predictors of in-hospital survival. ⋯ Among patients with a perioperative cardiac arrest, one in three survived to hospital discharge, and good neurological outcome was noted in two of three survivors.
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Editorial Comment
"Seeing" how our drugs work brings translational added value.
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Randomized Controlled Trial
Pregabalin rectifies aberrant brain chemistry, connectivity, and functional response in chronic pain patients.
Chronic pain remains a significant challenge for modern health care as its pathologic mechanisms are largely unknown and preclinical animal models suffer from limitations in assessing this complex subjective experience. However, human brain neuroimaging techniques enable the assessment of functional and neurochemical alterations in patients experiencing chronic pain and how these factors may dynamically change with pharmacologic treatment. ⋯ The results of this study suggest that pregabalin works in part by reducing insular glutamatergic activity, leading to a reduction of the increased functional connectivity seen between brain regions in chronic pain states. The study also supports a role for human brain imaging in the development, assessment, and personalized use of central-acting analgesics.