Anesthesiology
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Meta Analysis
Nitrous Oxide-related Postoperative Nausea and Vomiting Depends on Duration of Exposure.
Post-op nausea & vomiting incidence is related to duration of nitrous oxide exposure, but is clinically insignificant at under 1 hour exposure.
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Randomized Controlled Trial
Synergistic Interaction between Fentanyl and Bupivacaine Given Intrathecally for Labor Analgesia.
Intrathecal fentanyl synergistically improves labour analgesia when given in combination with bupivacaine.
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Multicenter Study Observational Study
Predicting Risk of Postoperative Lung Injury in High-risk Surgical Patients: A Multicenter Cohort Study.
The SLIP-2 score (Surgical Lung Injury Prediction) was found to offer acceptable accuracy in predicting the risk of post-operative ARDS in high-risk surgical patients (ROC 0.84).
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Multicenter Study Observational Study
GNAS Gene Variants Affect β-blocker-related Survival after Coronary Artery Bypass Grafting.
Cardiac overexpression of the β-adrenoreceptor (βAR)-coupled stimulatory G-protein subunit Gαs enhances inotropic responses to adrenergic stimulation and improves survival in mice under βAR blockade. The authors recently identified three common haplotypes in the GNAS gene encoding Gαs, with the greatest Gαs protein expression and signal transduction in haplotype *3 carriers and less in haplotype *2 and *1 carriers. The authors tested the hypothesis that these GNAS variants result in altered mortality in patients after coronary artery bypass graft surgery, particularly in those receiving βAR blockade. ⋯ GNAS haplotypes independently associate with an increased risk of death after primary coronary artery bypass graft surgery. These results are most pronounced in patients receiving βAR blockers, strengthening the rationale for personalized treatment, to decrease medication side effects and improve outcomes.
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Multicenter Study
Procedure-specific Risk Factor Analysis for the Development of Severe Postoperative Pain.
Many studies have analyzed risk factors for the development of severe postoperative pain with contradictory results. To date, the association of risk factors with postoperative pain intensity among different surgical procedures has not been studied and compared. ⋯ Independent of the type and extent of surgery, preoperative chronic pain and younger age were associated with higher postoperative pain. Females consistently reported slightly higher pain scores regardless of the type of surgery. The clinical significance of this small sex difference has to be analyzed in future studies.