Anesthesiology
-
Meta Analysis
Nitrous Oxide-related Postoperative Nausea and Vomiting Depends on Duration of Exposure.
Post-op nausea & vomiting incidence is related to duration of nitrous oxide exposure, but is clinically insignificant at under 1 hour exposure.
pearl -
Multicenter Study Observational Study
Predicting Risk of Postoperative Lung Injury in High-risk Surgical Patients: A Multicenter Cohort Study.
The SLIP-2 score (Surgical Lung Injury Prediction) was found to offer acceptable accuracy in predicting the risk of post-operative ARDS in high-risk surgical patients (ROC 0.84).
summary -
Randomized Controlled Trial
Synergistic Interaction between Fentanyl and Bupivacaine Given Intrathecally for Labor Analgesia.
Intrathecal fentanyl synergistically improves labour analgesia when given in combination with bupivacaine.
pearl -
Buprenorphine-naloxone (bup/nal in 4:1 ratio; Suboxone; Reckitt Benckiser Pharmaceuticals Incorporation, Richmond, VA) is approved by the Food and Drug Administration for outpatient office-based addiction treatment. In the past few years, bup/nal has been increasingly prescribed off-label for chronic pain management. ⋯ Possible mechanisms of pain relief by bup/nal therapy in opioid-dependent patients with chronic pain may include reversal of opioid-induced hyperalgesia and improvement in opioid tolerance and addiction. Additional studies are needed to assess the implication of bup/nal therapy in clinical anesthesia and perioperative pain management.